Akademik Bilgiler



HİLMİ ORHAN
PROFESÖR
Eczacılık Fakültesi
Eczacılık Meslek Bilimleri Bölümü
Farmasötik Toksikoloji Ana Bilim Dalı
İletişim Bilgileri- E-posta: hilmi.orhan@ege.edu.tr
- E-posta: horhan@gmail.com, alternatif e-posta
- Telefon: 0232 - 373 91 73, Anabilim Dalı tel.
- Telefon: 0232-3884000 / 1364, Dahili
- Web sayfası: www.turktox.org.tr, Türk Toksikoloji Derneği
Eğitim Bilgileri- Lisans: Hacetepe Üniversitesi, Eczacılık Fakültesi, Türkiye, 1990
- Yüksek Lisans: Hacettepe Üniversitesi, Sağlık Bilimleri Enstitüsü, Türkiye, 1994
- Doktora: Hacettepe Üniversitesi, Sağlık Bilimleri Enstitüsü, Türkiye, 2000
- Doçentlik: Hacettepe Üniversitesi, Toksikoloji Anabilim Dalı, Türkiye , 2005
- Profesörlük: Ege Üniversitesi, Türkiye , 2011

Mesleki Faaliyetleri (9 adet)- EUROTOX-Molecular Toxicology Speciality Section Başkanlığı, 2015-Devam Ediyor
- Environmental Toxicology and Pharmacology (Elsevier) Editorial Board üyesi, 2015-Devam Ediyor
- EUROTOX Yönetim Kurulu üyeliği, 2013-Devam Ediyor
- Türk Toksikoloji Derneği Başkanlığı, 2011-Devam Ediyor
- EUROTOX-Molecular Toxicology Specialty Section Sekreterliği, 2010-2015
- Tübitak Araştırma Projeleri Hakemliği, 2006-Devam Ediyor
- Türk Toksikoloji Derneği Genel Sekreterliği, 2005-2011
- Leonardo da Vinci Mesleki Eğitim Programı Bağımsız Dış Uzmanlığı, 2003-2006
- SCI kapsamındaki dergilerde hakemlik, 2000-Devam Ediyor
Uzmanlık Alanları- Farmasotik Toksikoloji (1030501)
İndekslerce Taranan Dergilerdeki Yayınları (34 adet)- Emre Durmaz, Rasih Kocagöz, Hilmi Orhan. Metal Pollution in Biotic and Abiotic Samples of the Büyük Menderes River, Turkey. Environmental Science&Pollution Research 2016; DOI. 10.1007/s11356-016-6417-7.
- Pavel Rossner, Hilmi Orhan, Gudrun Koppen, Kazuo Sakai, Regina M Santella, Antonin Ambroz, Andrea Rossnerova, Radim J Sram, Miroslav Ciganek, Jiri Neca, Ege Arzuk, Neliye Mutlu, Marcus S Cooke. Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine Analysis by an Improved ELISA: An inter-laboratory Comparison Study. Free Radical Biology&Medicine 2016; accepted.
- Beste Çağdaş, Rasih Kocagöz, İlgen Onat, Fatih Perçin, Okan Özaydın, Hilmi Orhan. Biological Monitoring of Persistent Organic Pollutants in Büyük Menderes River: Correlations to lipid and protein oxidation in Cyprinus carpio. Environmental Science&Pollution Research 2015 June 17 [Epub ahead print], DOI. 10.1007/s11356-015-4848-1.
- Orhan H. Editorial: Bioactivation of drugs: Enzymes, reactive metabolites and adverse reactions. Current Medicinal Chemistry 2015; 22(4): 406-407.
- Orhan H. Extrahepatic Targets and Cellular Reactivity of Drug Metabolites. Current Medicinal Chemistry 2015; 22(4): 408-437.
- Melis Karaca, Lokman Varışlı, Kemal Korkmaz, Okan Özaydın, Fatih Perçin, Hilmi Orhan. Organochlorine pesticides and antioxidant enzymes are inversely correlated with liver enzyme gene expression in Cyprinus carpio. Toxicology Letters 2014; 230(2): 198-207.
- Suna Sabuncuoglu, Ayse Eken, Ahmet Aydin, Hilal Ozgunes, Hilmi Orhan. Cofactor Metals and Antioxidant Enzymes in Cisplatin-Treated Rats: Effect of Antioxidant Intervention. Drug and Chemical Toxicology 2014; 27:1-8.
- Rasih Kocagöz, Ortaç Onmuş, İlgen Onat, Beste Çağdaş, Mehmet Sıkı, Hilmi Orhan. Environmental and Biological Monitoring of Persistent Organic Pollutants in Waterbirds by Non-invasive versus Invasive Sampling. Toxicology Letters 2014; 230(2): 208-217.
- Barregard L; Møller P; Henriksen T; Mistry V; Koppen G; Rossner, P. Jr.; Sram RJ; Weimann A; Poulsen HE; Andreoli R; Manini P; Marczylo T; Lam P; Evans MD; Kasai H; Kawai K; Li YS; Singh R; Teichert F; Farmer PB; Rozalski R; Gackowski D; Siomek A; Saez GT; Cerda C; Palmgren KB; Lindh C; Hossain B; Haghdoost S; Hu CW; Chao MR; Orhan H; Senduran N; Smith RJ; Olinski R; Loft S and Cooke MS. Human and methodological sources of variability in the measurement of urinary 8-oxo-7,8-dihydro-2’-deoxyguanosine. Antioxidants&Redox Signalling 2013; 18(18): 2377-2391.
- Sabuncuoglu S, Orhan H. Interference of metals and medications with the detection of lipid peroxidation in humans by photometric tbars assay. Current Analytical Chemistry 2013; 9(3): 457-462.
- Hilmi Orhan, Altan Sahin, Gonul Sahin, Ulku Aypar, Nico P.E. Vermeulen. Urinary Lipid and Protein Oxidation Products upon Halothane, Isoflurane and Sevoflurane Anesthesia in Humans-Potential Biomarkers for a Sub-clinical Nephrotoxicity- Biomarkers 2013; 18(1): 73-81.
- Orhan H, Vermeulen NP. Conventional and novel approaches in generating and characterization of reactive intermediates from drugs/drug molecules. Current Drug Metabolism 2011; 12: 383-394.
- [European Standards Committee on Urinary (DNA) Lesion Analysis (ESCULA), Evans MD, Olinski R, Loft S, Cooke MS. Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress. FASEB J 2010: 24(4): 1249-1260.
- Atasayar S, Gurer-Orhan H, Orhan H, Gurel B, Girgin G, Ozgunes H. Preventive effect of aminoguanidine compared to vitamin E and C on cisplatin-induced nephrotoxicity in rats. Experimental and Toxicologic Pathology 2009: 61: 23-32.
- O. Yesil-Celiktas, G. Girgin, H. Orhan, H. J. Wichers, E. Bedir, F. Vardar-Sukan. Screening of free radical scavenging capacity and antioxidant activities of Rosmarinus officinalis extracts with focus on location and harvesting times. European Food Research and Technology 2007: 224: 443-451.
- Orhan H. Analyses of Representative Biomarkers of Exposure and Effect by Chromatographic, Mass Spectrometric and Nuclear Magnetic Resonance Techniques: Method Development and Application in Life Sciences. Journal of Separation Science 2007: 30: 149-174.
- Akdemir Ozisik P, Inci S, Soylemezoglu F, Orhan H, Ozgen T. Comparative dural closure techniques: a safety study in rats. Surgical Neurology 2006: 65: 42-47.
- Hande Gurer-Orhan, Nuran Ercal, Suneetha Mare, Subramaniam Pennathur, Hilmi Orhan, Jay W. Heinecke. Misincorporation of free meta-tyrosine into cellular proteins: A potential cytotoxic mechanism for oxidized amino acids. Biochemical Journal 2006: 395(2): 277-284.
- Hande Gürer-Orhan, Hilmi Orhan, M. Orhan Püsküllü, Erdem Büyükbingöl, Sibel Süzen. Synthesis and Evaluation of In vitro Antioxidant Capacities of New Benzimidazole Derivatives. Enzyme Inhibition and Medicinal Chemistry 2006: 21(2): 241-247.
- Orhan H., Gurer-Orhan H., Vriese E., Vermeulen N.P.E., Meerman J.H.N. Application of lipid peroxidation and protein oxidation biomarkers for oxidative damage in mammalian cells-A comparison with two fluorescent probes-. Toxicology In Vitro 2006: 20(6): 1005-1013.
- Gurer-Orhan H., Orhan H., Vermeulen N.P.E., Meerman J.H.N. Screening the Oxidative Potential of Several Mono- and Di-Halogenated Biphenyls and Biphenyl Ethers in Rat Hepatocytes. Combinatorial Chemistry and High Throughput Screening 2006: 9: 449-454.
- Orhan H., Coolen S., Meerman J.H.N. Quantification of Urinary o,o'-dityrosine, a biomarker for oxidative damage to proteins, by high performance liquid chromatography with triple quadrupole tandem mass spectrometry- A comparison with ion-trap tandem mass spectrometry- Journal of Chromatography B, Analytical Technology in the Biomedical & Life Sciences 2005: 827: 104-108.
- Orhan H., Evelo C.T.A., Sahin G. Erythrocyte Antioxidant Defense Response Against Cigarette Smoking in Humans-The Glutathione S-Transferase Vulnerability-. Journal of Biochemical and Molecular Toxicology 2005: 19(4): 226-233.
- Orhan H., Vermeulen N.PE., Tump C., Zappey H., Meerman J.H.N. Simultaneous determination of tyrosine and phenylalanine oxidation products and 8-hydroxy-2:-deoxyguanosine in biological samples as non-invasive multi-parameter biomarker for oxidative damage. Journal of Chromatography B, Analytical Technology in the Biomedical & Life Sciences 2004: 799(2): 245-254.
- Orhan H., Commandeur J.N.M., Sahin G., Aypar U., Sahin A., Vermeulen N.P.E. Use of 19F- NMR and GC-ECD techniques in the quantitative analysis of fluorine containing metabolites in urine of sevoflurane-anesthetized patients Xenobiotica 2004: 34 (3): 301-316.
- Orhan H., van Holland B., Krab B., Moeken J., Vermeulen N.P.E., Hollander P., Meerman J.H.N. Evaluation of a multi-parameter biomarker set for oxidative damage in man: Increased urinary excretion of lipid, protein and DNA oxidation products after one hour of exercise Free Radical Research 2004: 38 (12): 1269-1279.
- Orhan H., Onderoglu L., Aykan Y., Sahin G. Circulating biomarkers of oxidative stress in complicated pregnancies. Archives of Gynecology and Obstetrics 2003: 267: 189-195.
- Orhan H., Vermeulen N.P.E., Sahin G., Commandeur J.N.M. Characterisation of thioether compounds formed from potentially nephrotoxic alkaline degradation products of enflurane. Anesthesiology 2001: 95(1): 165-175.
- Aydin A., Orhan H., Sayal A., Ozata M., Sahin G., Isimer A. Antioxidant system and nitric oxide related parameters in type II diabetes mellitus: Effects of glycemic control. Clinical Biochemistry 2001: 34: 65-70.
- Orhan H., Sahin G. In vitro effects of NSAIDs and paracetamol on oxidative stress-related parameters of human erythrocytes. Experimental and Toxicologic Pathology 2001: 53(2-3): 133-140.
- Orhan H., Marol S., Hepsen I.F., Sahin G. Effects of some probable antioxidants on selenite-induced cataract formation and oxidative stress-related parameters in rats. Toxicology 1999: 139(3): 219-232.
- Orhan H., Inanici F., Arslan S., Hascelik Z., Sahin G. In vivo effects of non-steroidal anti-inflammatory drugs on oxidative stress-related parameters of human erythrocytes. Experimental and Toxicologic Pathology 1999, 51(4-5): 403-408.
- Orhan H., Dogruer D.S., Cakir B., Sahin G., Sahin M.F. The in vitro effects of non-steroidal anti-inflammatory compounds on antioxidant system of human erythrocytes. Experimental and Toxicologic Pathology 1999, 51(4-5): 397-402.
- Orhan H., Sahin G., Duru S. Assessment of the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on human erythrocyte glutathione S-transferase rho activity in vitro. Experimental and Toxicologic Pathology 1996, 48: 381-385.

Tamamlanmış Araştırma Projeleri (4 adet)- 2014, Tübitak projesi, No: 114S310, Türkiye Bilimsel ve Teknik Araştırma Grubu (TÜBİTAK), Sağlık Bilimleri Araştırma Grubu, SBAG 114S310. Kanser Hastalarında Kalıcı Organik Kirletici Düzeyleri, Maruziyet, Genetik Yatkınlık ve Moleküler Hasarın Biyogöstergeleri.
- 2012, Tübitak Projesi, No: 112Y199, Türkiye Bilimsel ve Teknik Araştırma Grubu (TÜBİTAK), Çevre, Atmosfer, Yer ve Deniz Bilimleri Araştırma Grubu, ÇAYDAG 112Y199. Büyük Menderes Nehir Havzasında ve Canlılarda Metal Kirliliğinin Analizi.
- 2011, Tübitak projesi, No: 110S224, Türkiye Bilimsel ve Teknik Araştırma Grubu (TÜBİTAK), Sağlık Bilimleri Araştırma Grubu, SBAG 110S224. Bazı İlaç Etken Maddelerinin Metabolik Profillerinin ve Kritik Hücresel Makromoleküllerle Etkileşme Potansiyellerinin Belirlenmesi.
- 2008, Tübitak Projesi, No: 108Y049, Türkiye Bilimsel ve Teknik Araştırma Grubu (TÜBİTAK), Çevre, Atmosfer, Yer ve Deniz Bilimleri Araştırma Grubu, ÇAYDAG 108Y049. Büyük Menderes Sucul Ortamında Kalıcı Organik Kirletici ve Endokrin Bozucu Bileşiklerin Neden Olduğu Çevresel Kirlenmenin Analizi, Biyogöstergeler Aracılığıyla İzlenmesi ve Toksik Etkilerinin Belirlenmesi.
Bilimsel Kuruluş Üyeliklerim (6 adet)- Farmasötik Bilimler Ankara Derneği (FABAD)
- Federation of European Toxicologists and European Societies of Toxicology (EUROTOX)
- International Society for the Studies on Xenobiotics (ISSX)
- International Union of Toxicology (IUTOX)
- Society of Environmental Toxicology and Chemistry (SETAC)
- Türk Toksikoloji Derneği (TTD)
Kazanılan Burslar (1 adet)- 1996, NATO-A2 araştırma bursu
Kazandığı Ödüller (2 adet)- 2008, Bo Holmstedt Memorial Lectureship Award
- 2007, IUTOX / Astra Zeneca Award
Yöneterek Sonuçlandırdığı Öğrenci Tezleri (8 adet)- Yüksek Lisans, 2014, 2. Esra Avcı “İlaç biyoaktivasyonunda çeşitli oksidazların rolü”, Department of Toxicology, Faculty of Pharmacy, Ege University, Izmir-Turkey, 2012-2015.
- Yüksek Lisans, 2014, Neliye Mutlu “Elektrokimyasal yöntem ve mikrozomal fraksiyon aracılıklı ilaç metabolitleri üretimi ve enzimatik karakterizasyonu”, Department of Toxicology, Faculty of Pharmacy, Ege University, Izmir-Turkey, 2012-2014.
- Yüksek Lisans, 2012, Beste Cagdas “Buyuk Menderes sucul canlılarında poliklorlu bifenil kirliliği ve lipit oksidatif hasarı”, Department of Toxicology, Faculty of Pharmacy, Ege University, Izmir-Turkey, 2009-2012.
- Yüksek Lisans, 2011, Rasih Kocagoz “Buyuk Menderes havzasında çoklu bromlu bifenil kirliliği ve sucul sistem canlılarında protein oksidasyonu üzerine etkileri”, Department of Toxicology, Faculty of Pharmacy, Ege University, Izmir-Turkey, 2009-2011.
- Yüksek Lisans, 2010, Melis Karaca. “Sucul sistem canlılarında organoklorlu pestisitlerin analizi ve antioksidan enzim aktivitelerinin biyogösterge amaçlı uygulanması”, Ege Üniversitesi Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim dalı, 2007-2010
- Yüksek Lisans, 2003, Berry van Holland, Betty Krab, Janine Moeken. “Non-invasive biomarkers for oxidative damage after endurance cycling”, Leiden Amsterdam Center for Drug Research, Department of Molecular Toxicology, Amsterdam-The Netherlands, October 2002-April 200...
- Yüksek Lisans, 2003, Eveline Vriese. “Chinese Hamster Ovary cell (CHO) systems as an in vitro model for oxidative stress studies”, Leiden Amsterdam Center for Drug Research, Department of Molecular Toxicology, Amsterdam-The Netherlands, September 2002-March 2003.
- Yüksek Lisans, 2001, Wendy Caan. “Biomarkers for exercise-, and menadione-induced oxidative stress”, Leiden Amsterdam Center for Drug Research, Department of Molecular Toxicology, Amsterdam-The Netherlands, May-September 2001.