Akademik Bilgiler



HANDE GÜRER ORHAN
PROFESÖR
Eczacılık Fakültesi
Eczacılık Meslek Bilimleri Bölümü
Farmasötik Toksikoloji Ana Bilim Dalı
İletişim Bilgileri- E-posta: hgurer@gmail.com
- E-posta: hande.gurer.orhan@ege.edu.tr
- Telefon: (232) 373 9173 (sekreterlik) Dahili: 1364 (sekreterlik) 4074 (oda)
Eğitim Bilgileri- Lisans: Hacettepe Üniversitesi, Eczacılık Fakültesi, Türkiye, 1992
- Yüksek Lisans: Hacettepe Üniversitesi, Eczacılık Fakültesi, Toksikoloji AD, Türkiye, 1994
- Doktora: Hacettepe Üniversitesi, Eczacılık Fakültesi, Toksikoloji AD, Türkiye, 1999
- Doçentlik: Hacettepe Üniversitesi, Eczacılık Fakültesi, Türkiye, 2005
- Profesörlük: Ege Üniversitesi, Eczacılık Fakültesi, Türkiye , 2011

Uzmanlık Alanları- Farmasotik Toksikoloji (1030500)
İndekslerce Taranan Dergilerdeki Yayınları (30 adet)- Suzen S, Gurer-Orhan H, Saso L. Detection of Reactive Oxygen and Nitrogen Species by Electron Paramagnetic Resonance (EPR) Technique. Molecules. 2017 Jan 21;22(1). pii: E181. doi: 10.3390/molecules22010181.
- Eroğlu I, Azizoğlu E, Ozyazıcı M, Nenni M, Gürer Orhan H, Ozbal S, Tekmen I, Ertam I, Unal I, Ozer O. “Effective topical delivery systems for corticosteroids: dermatological and histological evaluations.” Drug Deliv. 23(5): 1502-1513 (2016).
- Shirinzadeh H, Ince E, Westwell AD, Gurer-Orhan H, Suzen S. Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities. J Enzyme Inhib Med Chem. Jan 8:1-10. [Epub ahead of print] (2016).
- Puskullu MO, Shirinzadeh H, Nenni M, Gurer-Orhan H, Suzen S. Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues. J Enzyme Inhib Med Chem. 31(1): 121-125 (2016).
- Gurer-Orhan H, Karaaslan C, Ozcan S, Firuzi O, Tavakkoli M, Saso L, Suzen S. Novel indole-based melatonin analogues: Evaluation of antioxidant activity and protective effect against amyloid β-induced damage. Bioorg Med Chem. 24(8):1658-1664 (2016).
- Rençber S, Karavana SY, Yılmaz FF, Eraç B, Nenni M, Özbal S, Pekçetin Ç, Gurer-Orhan H, Hoşgör-Limoncu M, Güneri P, Ertan G. Development, characterization, and in vivo assessment of mucoadhesive nanoparticles containing fluconazole for the local treatment of oral candidiasis. Int J Nanomedicine. 11: 2641-2653 (2016).
- Gurer-Orhan H, Suzen S. “Melatonin, its metabolites and its synthetic analogs as multi-faceted compounds: antioxidant, prooxidant and inhibitor of bioactivation reactions”. Current Medicinal Chemistry 22(4): 490-499 (2015).
- Gurer-Orhan H, Suzen S. “Melatonin, its metabolites and its synthetic analogs as multi-faceted compounds: antioxidant, prooxidant and inhibitor of bioactivation reactions”. Current Medicinal Chemistry 22(4): 490-499 (2015).
- “Antioxidant activity of indole-based melatonin analogues in erythrocytes and their voltammetric characterization.” J Enzyme Inhib Med Chem. 2012 Sep 20.
- Novel Indole-Based Analogs of Melatonin: Synthesis and in Vitro Antioxidant Activity Studies. Molecules 15, 2187-2202 (2010).
- Some nonylphenol isomers show antiestrogenic potency in the MVLN cell assay. Toxicol In Vitro, 24, 129–134 (2010).
- 2008, Atasayar S, Gurer-Orhan H, Orhan H, Gurel B, Girgin G, Ozgunes H. Preventive Effect of aminoguanidine compared to vitamin E and C on cisplatin-induced nephrotoxicity in rats. Exp Toxicol Pathol
- 2006, Misincorporation of free m-tyrosine into cellular proteins: a potential cytotoxic mechanism for oxidized amino acids. Biochem J. : 395: 277-84.
- 2006, Synthesis and evaluation of in vitro antioxidant capacities of some benzimidazole derivatives. J Enzyme Inhib Med Chem. 21: 241-7.
- 2006, Application of lipid peroxidation and protein oxidation biomarkers for oxidative damage in mammalian cells. A comparison with two fluorescent probes. Toxicol In Vitro.: 20: 1005-13.
- 2006, Screening the oxidative potential of several mono- and di-halogenated biphenyls and biphenyl ethers in rat hepatocytes. Comb Chem High Throughput Screen. Jul:9(6):449-54.
- 2005, A novel microplate reader-based high-throughput assay for estrogen receptor binding Int J Environ Anal Chem. 85 : 149-161.
- 2004, Correlation between clinical indicators of lead poisoning and oxidative stress parameters in controls and lead-exposed workers. Toxicology.: 195:147-54.
- 2002, Oxidative stress in a phenylketonuria animal model. Free Radic Biol Med.:32: 906-11.
- 2001, Antioxidant effect of taurine against lead-induced oxidative stress. Arch Environ Contam Toxicol.: 41: 397-402.
- 2001, Correlation between plasma malondialdehyde and ceruloplasmin activity values in preeclamptic pregnancies. Clin Biochem.:34: 505-6.
- 2001, Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem.:1: 529-39.
- 2000, Can antioxidants be beneficial in the treatment of lead poisoning? Free Radic Biol Med.: 29: 927-45.
- 1999, Effects of some sulfur-containing antioxidants on lead-exposed lenses. Free Radic Biol Med. 26: 239-43.
- 1999, Captopril as an antioxidant in lead-exposed Fischer 344 rats. Hum Exp Toxicol. 18: 27-32
- 1999, Antioxidant role of alpha-lipoic acid in lead toxicity. Free Radic Biol Med.: 27: 75-81
- 1998, Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats. Toxicology. 128:181-9.
- 1998, Effects of N-acetylcysteine and 2,3-dimercaptosuccinic acid on lead induced oxidative stress in rat lenses. Toxicology, 130:167-74.
- 1997, Pro-oxidant effects of delta-aminolevulinic acid (delta-ALA) on Chinese hamster ovary (CHO) cells. Toxicol Lett. 91:169-78.
- Correlation between plasma malondialdehyde and ceruloplasmin activity values in rheumatoid arthritis. Clin Biochem. 1995 Apr:28(2):193-4

İndekslerce Taranmayan Dergilerdeki Yayınları (1 adet)- 2009,

Bilimsel Kuruluş Üyeliklerim (4 adet)- EUROTOX
- Farmasötik Bilimler Ankara Derneği (FABAD)
- IUTOX
- Türk Toksikoloji Derneği
Kazanılan Burslar (1 adet)- 1996, NATO A2
Kazandığı Ödüller (1 adet)- 2008, SOT Astra-Zeneca Fellowship Award
Yöneterek Sonuçlandırdığı Öğrenci Tezleri (2 adet)- Yüksek Lisans, 2011, Bitkisel Gıda Destek Ürünlerinin Endokrin Bozucu Etki Potansiyellerinin In Vitro Olarak Belirlenmesi- Biyomühendis Yasemin TOKER
- Yüksek Lisans, 2009 , Fitoöstrojenlerin Tek Başlarına ve KArışımları Halinde Neden Oldukları Bifazik Etkilerinin Araştırılması- Eczacı Burcu EREN