Akademik Bilgiler



PETEK BALLAR KIRMIZIBAYRAK
DOÇENT
Eczacılık Fakültesi
Temel Eczacılık Bölümü
Biyokimya Ana Bilim Dalı
İletişim Bilgileri- E-posta: petek.ballar@ege.edu.tr
Eğitim Bilgileri- Lisans: Ege Üniversitesi, Eczacılık Fakültesi, Türkiye, 2001
- Doktora: University of Maryland, Baltimore , Molecular Medicine, A.B.D., 2007
- Yardımcı Doçentlik: Ege Üniversitesi, Eczacılık Fakültesi, Biyokimya ABD, Türkiye, 2009

İdari ve Akademik Görevleri (4 adet)- Doçent, 2012-
- Yardımcı Doçent, 2009-
- Araş. Gör.Dr., 2007-2009
- Araş. Gör, 2001-2007
Uzmanlık Alanları- Biyokimya (1010400)
- Moleküler Biyoloji (4010200)
- Hücre Biyolojisi (4010201)
İndekslerce Taranan Dergilerdeki Yayınları (20 adet)- 2014, Baykan Erel, S., Demir, S., Nalbantsoy, A., Ballar, P., Khan, S., Karabay Yavasoglu, U., Karaalp, C. (2014) “Bioactivity screening of five Centaurea species and in vivo anti-inflammatory activity of C. athoa” Phar. Biol., Epub.
- 2014, Chen, Z., Ballar, P., Fu, Y., Luo, J., Du, S., Fang, S. “The E3 Ubiquitin Ligase gp78 Protects Against ER Stress in Zebrafish Liver”. J Genet Genomics, in press
- 2014, Istanbullu, H., Erzurumlu, Y., Ballar Kirmizibayrak, P., Erciyas, E. “Evaluation of Alkylating and Intercalating Properties of Mannich Bases for Cytotoxic Activity”. Lett Drug Des Discov, in press
- 2013, Akgul, O., Tarikogulları, A., Aydın-Kose, F., Kirmizibayrak-Ballar, P., Pabuccuoglu, V. (2013) Synthesis and Cytotoxic Activity of Some 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetamide Derivatives. Turk J Chem, 37:204-212
- 2013, Erzurumlu, Y., Aydin-Kose, F., Gozen, O., Gozuacik, D.,Toth, E.A., Ballar, P. (2013) “A Unique IBMPFD-related p97/VCP mutation with differential binding pattern and subcellular localization” Int. J. Biochem Cell Biol. , 45(4):773-82
- 2012, Kilic, T., Topkaya S.N., Ozkan-Ariksoysal, D., Ozsoz, M, Ballar, P., Erac, Y., Gozen, O. (2012) Electrochemical Based Detection of MicroRNA, mir21 in Breast Cancer Cells. Biosens. Bioelectron. 38: 195-201.
- 2011, Ballar, P., Pabuccuoglu, A., Kose, F.A. Different p97/VCP complexes function in retrotranslocation step of mammalian ER-associated degradation (ERAD). Int J Biochem Cell Biol 43(4):613-21
- 2011, Cizmecioğlu M, Pabuçcuoğlu V, Ballar P, Pabuççuoğlu A, Soyer Z. Synthesis and screening of cyclooxygenase inhibitory activity of some 1,3-dioxoisoindoline derivatives. Arzneimittelforschung 61(3):186-90
- 2011, Zhong, Y., Wang, Y., Yang, H., Ballar, P., Lee, J.G., Ye, Y., Monteiro, M.J., Fang, S. Importin {beta} interacts with the ER-associated degradation machinery and promotes ubiquitination and degradation of mutant {alpha}1-antitrypsin. J Biol Chem 286(39):33921-30
- 2011, Wang, Y., Ballar, P., Zhong, Y., Zhang, X., Liu, C., Zhang, YJ., Monteiro, MJ., Li, J., Fang, S. (2011) SVIP Induces Localization of p97/VCP to the Plasma and Lysosomal Membranes and Regulates Autophagy. PLoS One,6(8):e24478.
- 2010, Ballar, P., Uygar Ors, A., Yang, H., Fang, S. (2010). Differential regulation of CFTRDeltaF508 degradation by ubiquitin ligases gp78 and Hrd1. Int. J. Biochem Cell Biol. 42 (1) ,167-173
- 2010, Gülcemal, D., Alankuş-Çalışkan, O., Karaalp, C., Ors, A.U., Ballar, P., Bedir, E. Phenolic Glycosides with antiproteasomal activity from Centaurea urvillei DC. subsp. urvillei. Carbohydr Res 345(17):2529-33
- 2008, Ballar, P. and Fang, S. (2008) Regulation of ER-Associated Degradation Via p97/VCP-Interacting Motif, minireview, Biochem Soc Trans 36 (Pt5): 818-22
- 2007, Yang, H., Zhong, X., Ballar, P., Luo, S., Shen, Y., Rubinsztein, DC., Monteiro, MJ., Fang, S. (2007). Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin. Exp Cell Res 313,538-550.
- 2007, Shen, Y., Ballar, P., Apostolou, A., Doong, H., Fang, S. (2007). ER stress differentially regulates the stabilities of ERAD ubiquitin ligases and their substrates. Biochem Biophys Res Commun 352(4):919-24
- 2007, Ballar, P., Yongwang, Z., Nagahama, M., Tagaya, M., Shen, Y., Fang, S. (2007). Identification of SVIP as an endogenous inhibitor of ER-associated degradation. J Biol Chem 282(47):33908-14
- 2006, Shen, Y., Ballar, P., Fang, S. (2006). Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha-1-antitrypsin. Biochem Biophys Res Commun 349(4):1285-93.
- 2006, Ballar, P., Shen, Y., Yang, H., Fang, S. (2006). The Role of a Novel p97/Valosin-containing Protein-interacting Motif of gp78 in Endoplasmic Reticulum-associated Degradation. J Biol Chem 281 (46) :35359-68.
- 2005, Strauch, MA., Ballar, P., Rowshan, AJ., Zoller, KL. (2005). The DNA-binding specificity of the Bacillus anthracis AbrB protein. Microbiology 151(Pt 6):1751-9.
- 2004, Zhong, X., Shen, Y., Ballar, P., Apostolou, A., Agami, R., Fang, S. (October 2004). AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. J Biol Chem 279: 45676-45684.

İndekslerce Taranmayan Dergilerdeki Yayınları (4 adet)- 2014, Baykan Erel, S., Ballar, P., Karaalp, C. “Antioxidant activities of phenolic compounds of Centaurea ensiformis P.H. Davis” Turkish J of Pharmaceutical Sciences , 11(1): 18-24.
- 2013, Erzurumlu, Y., Ilhan, R., Gozen, O., Ballar, P. (2013) VCP (valosin containing protein). Atlas Genet Cytogenet Oncol Haematol. 17(8): 550-556.
- 2011, Baykan Erel, Ş., Şenol, S.G., Aydın Köse, F., Ballar, P. In vitro Cytotoxic Properties of Six Artemisia L. Species. Turk. J. Pharm. Sci. 8(3): 247-251
- 2011, 2012, Erzurumlu, Y., Ballar, P.AMFR (autocrine motility factor receptor). Atlas Genet Cytogenet Oncol Haematol. 16(1): 25-29.

Diğer Dergiler ve Medyalardaki Yayınları (1 adet)- 2011, Ballar, P. Kistik fibrozis, İlaç Haber Aktüel. 7(26): 62-63

Uluslararası Toplantılarda Sunulan Bildirileri (25 adet)- Kırmızıbayrak Ballar P., (November 2013) “Regulation of mammalian ERAD” INTEGRATING EUROPEAN UBIQUITIN NETWORKS: TOWARDS HORIZON 2020, Bilbao, SPAIN
- Erel Baykan, S., Demir, S., Nalbantsoy, A., Ballar, P., Khan, Shabana, Karaalp, C., Karabay-Yavasoglu, U. (June 2012) “Cytotoxic, antioxidant, antiinflamatory capacities of five Centaurea L. species and in vivo anti-inflaamatory evaluation of Centaurea Athoa” 10th International Symposium on Pharmaceutical Sciences (ISOPS), Ankara, Turkey (oral).
- Aydin-Kose, F., Pabuccuoglu, A., Ballar, P. (November 2012) “Different p97/VCP complexes function in retrotransloaction step of mammalian ER-associated degradation (ERAD)” FEBS Special Meeting on Protein Quality Control and Ubiquitin Systems in Health and Disease, Aydin, Turkey (poster)
- Erzurumlu, Y., Aydin-Kose, F., Gozen, O., Gozuacik, D.,Toth, E.A., Ballar, P. (November 2012) “A Unique IBMPFD-related p97/VCP mutatipn with differential binding pattern and subcellular localization” FEBS Special Meeting on Protein Quality Control and Ubiquitin Systems in Health and Disease, Aydin, Turkey (oral)
- Aydin-Kose, F., Pabuccuoglu, A., Ballar, P. (October 2011) “Differential regulation and complex composition in gp78- and Hrd1-mediated ER-associated degradation” EMBO Workshop on Intracellular Proteolysis & Cancer, Valencia, Spain (poster)
- Erel Baykan, S.,Demir, S., Kose Aydin, F. Ballar, P., Karaalp, C. (August 2011) “Cytotoxic properties of five Centaurea L. species from Anatolia.” 9th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research, Antalya, Turkey (poster).
- Akgul, O., Tarikogullari, A.H., Ballar, P., Aydin-Kose, F., Soyer, Z. (June 2010). The synthesis and proteasome inhibitory activity of some alkanamide derivatives. IPSMPS, Izmir, Turkey (oral)
- Arslan, G., Baykan-Erel, S., Ballar, P. (June 2010) Cytotoxic activities of Artemisia L. species in MCF 7 breast cancer cells. IPSMPS, Izmir, Turkey (oral)
- Soyer, Z., Akgul, O., Ballar, P. (June 2010). Synthesis and screening of cyclooxgenase inhibitory activitiy of some amide derivatives. IPSMPS, Izmir, Turkey (poster)
- Ors, A.U., Ballar, P. (June 2010). Role of IBMPFD-associated VCP mutations on ERAD pathway. IPSMPS, Izmir, Turkey (poster)
- Uysal, Ş., Arslan, G., Ballar, P., Soyer, Z. (September 2010). Synthesis and cytotoxic activity of some 3-(Acylamino)propionanilide derivatives. IMMPC-ISPC Joint meeting, Ankara, Turkey (poster)
- Fang, S., Ballar, P. (May 2009). Ubiquitin Ligases as targets for drug discovery. III. International Congress of Molecular Medicine, İstanbul, Turkey (oral)
- Ballar, P., Yongwang, Z., Shen, Y., Fang, S. (May 2009). The first identified endogenous Endoplasmic Reticulum (ER)-associated degradation (ERAD) inhibitor: SVIP. III. International Congress of Molecular Medicine, İstanbul, Turkey (oral)
- Ballar, P. and Fang, S. (May 2009). Analysis of differences in retrotranslocation machineries of gp78- and Hrd1-mediated ERAD pathways by RNA interference, The Fourth Intracellular proteolysis meeting: Ubiquitin-Proteasome system, dynamics and targeting, Barcelona, Spain.(poster)
-  Ballar, P., Zhong, Y., Fang, S. (September 2009). Analysis of the ubiquitin ligases gp78- and Hrd1-mediated ERAD pathways by RNA interference. EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Health and Disease, Riva Del Garda, Italy (poster)
- Baykan Erel, Ş., Ballar, P., Karaalp, C. (June 2009). Antioxidant compounds from endemic Centaurea ensiformis P.H. Davis. 9th ISOPS, Ankara, Turkey (poster)
- Ballar, P., Yang, H., Shen, Y., Fang, S. (March 2008). The Regulation of ER-associated degradation (ERAD) via the p97/VCP-interacting motif (VIM) Biochemical Society “Third intracellular proteolysis meeting” , Santa Cruz de Tenerife, Canary Islands, Spain (oral)
- Ballar, P., Zhong, Y., Nagahama, M., Tagaya, M., Shen, Y., Fang, S. (April 2007). SVIP serves as a brake for gp78-mediated degradation of misfolded ER proteins. Graduate Research Conference, University of Maryland, Baltimore, USA (oral)
- Apostolou, A. , Ballar, P. , Fang, S. (April 2007). Supresin, An Er Stress Upregulated Protein, Inhibits Cell Growth And Protects Cells Against Er Stress-Induced Cell Death. Graduate Research Conference, University of Maryland, Baltimore, USA (oral)
- Ballar, P., Shen Y.X., Yongwang, Z.W., Nagahama, M., Tagaya, M., Apostolou, A., Fang, S. (November 2007). "SVIP interacts with Derlin1 and regulates ER-associated degradation." . FASEB Journal 21 (6): A1023-A1024 Experimental Biology Meeting, Washington D.C., USA (poster)
- Yang, H., Zhong, X., Ballar, P., Luo, S., Shen, Y., Rubinsztein, DC., Monteiro, MJ., Fang, S. (April 2007). "The extended quality control role of the ER-anchored ubiquitin ligase Hrd1 in the targeting of expanded huntingtin for degradation. FASEB Journ Experimental Biology Meeting, Washington D.C., USA (poster)
- Ballar, P., Zhong, Y., Nagahama, M., Tagaya, M., Shen, Y., Fang, S. (July 2007). SVIP inhibits ERAD by uncoupling Derlin1 and p97/VCP from gp78. FASEB Summer Research Conferences: "From Unfolded Proteins in the Endoplasmic Reticulum to Disease", Indian Wells, California, USA (poster)
- Ballar, P., Shen, Y., Yang, H., Fang, S., (June 2006). Ubiquitin ligase gp78 mediates a Ufd1-independent ER-associated degradation. FEBS Journal 273: 59-59 Suppl. FEBS Congress, Molecules in Health & Disease, Istanbul, Turkey (oral)
- Ballar, P., Zhong, X., Shen, Y., Apostolou, A., Agami, R., Fang, S. (March 2005). "gp78, more than a ubiquitin ligase". FASEB Journal 19 (4): A317-A317 Part 1 Suppl. Experimental Biology Meeting, San Diego, USA (oral)
- Apostolou, A., Shen, Y., Ballar, P., Fang, S. (March 2005). Synergistic effect of ubiquitinating enzymes and ER stress in ERAD. Experimental Biology Meeting, San Diego, USA (poster)

Ulusal Toplantılarda Sunulan Bildirileri (3 adet)- Kırmızıbayrak Ballar P., (October 2013) “The role of p97/VCP, one of the key proteins of Endoplasmic reticulum associated degradation, on IBMPFD” XIII. ULUSAL TIBBİ BİYOLOJİ ve GENETİK KONGRESİ (XIII. NATIONAL CONGRESS of MEDICAL BIOLOGY and GENETICS), Aydin, Turkey (invited talk)
- Aydin-Kose, F., Pabuccuoglu, A., Ballar, P. (December 2011) “Investigation of protein nitration in several mammalian cell lines” XXIII. NATIONAL BIOCHEMISTRY CONGRESS, Adana, Turkey (poster)
- Ballar, P. (October 2008). “Ubiquitin and proteasome system”, 20th National Biochemistry Congress, Nevsehir, Turkey (invited talk).

Kaynak Gösterilme AdetleriKendisi tarafından 33 kez kaynak gösterilmiştir.
Başkaları tarafından 347 kez kaynak gösterilmiştir.
Kitapları (2 adet)- Erzurumlu, Y., Ballar, P. Electrochemical DNA Biosensors (Introduction to Molecular Biology Related to Electrochemical DNA-Based Biosensors), Chapter 16. Pan Stanford Publishing, 2012
- Carrigan, P.E., Ballar, P., Tuzmen, S. “Chapter 8: Site Directed Mutagenesis.” Disease Gene Identification Methods and Protocols by J.K. DiStefano. 107-124 pp., Humana Press, A.B.D., 2011

Tamamlanmış Araştırma Projeleri (6 adet)- 2010, TÜBİTAK, 110S096 , “Functional genomic analysis of miRNA expressional profile associated with post-transcriptional control of TRPC ion channel genes in human primary aortic smooth muscle cells/ İnsan primer aortik düz kas hücrelerinde TRPC iyon kanal genlerinin post-transkripsiyonel kontrolü ile ilişkili miRNA-ekspresyon kalıbının işlevsel genomik analizi" (Project Partner)
- 2010, TÜBİTAK, 110T405 , "Analysis of links and cross-talk between autophagy and ubiquitin-proteasome systems, the basic mechanisms of intracellular protein degradation/ Hücre İçi Protein Yıkımından Sorumlu Temel Mekanizmalar Olan Otofaji ve Übikitin-Proteazom Sistemleri Arasındaki Bağlantı ve İletişimin Araştırılması" (Project Partner)
- 2009, FP7-PEOPLE-IRG 239409 , Expanding the knowledge on mammalian Endoplasmic Reticulum-associated degradation (ERAD) (Project coordinator)
- 2008, TUBİTAK 107T934, "The synthesis and biological activity of some phthalimidoalkanamide derivatives/ Bir Grup Ftalimidoalkanamit Türevi Bileşiklerin Sentezi ve Biyolojik Aktivitelerinin Tayin Edilmesi", (Project Partner)
- 2008, Tübitak, 108S056, "Identification of the regulation mechanisms and molecular details of Endoplasmic Reticulum-associated degradation (ERAD)/ Memeli hücrelerinde Endoplazmik Retikulum İlişkili Protein Yıkım (ERİY) mekanizmasının substrata spesifik farklılıklarının ve regülasyonunun incelenmesi (Project Coordinator)
- 2008, Ege Üniversitesi, BAP Destekleri, 08-ECZ-021 , Potansiyel biyolojik aktif bazı sentetik ve bitkisel kaynaklı bileşiklerin hücre apoptozisi üzerindeki etkilerinin araştırılması
Bilimsel Kuruluş Üyeliklerim (6 adet)- American Society for Biochemistry and Molecular Biology (ASBMB)
- Biochemical Society
- Biochemical Society, UK
- Federation of Europian Biochemical Society (FEBS)
- Moleküler Biyoloji Derneği
- Türk Biyokimya Derneği
Kazanılan Burslar (1 adet)- 2003, YÖK bursu
Kazandığı Ödüller (11 adet)- 2013, Prof. Dr. Baki Komsuoglu Young Scientist Award
- 2012, Turkish Pharmacists’ Association Young Scientist Award
- 2011, EMBO Travel Grant, “EMBO Workshop on Intracellular Proteolysis and Cancer. From basic research to patient care.”, İspanya
- 2010, L’oreal Turkey For Woman In Science Fellowship
- 2008, Portland Press Young Investigator Award http://www.biochemj.org/bj/news/poster_winners/Ballar_P.htm
- 2008, Distinguished Young Scientists Award of the Turkish Academy of Sciences (TUBA-GEBIP)
- 2007, University of Maryland Biotechnology Institute (UMBI) Distinguished service award
- 2005, The American Society for Biochemistry and Molecular Biology Graduate/Postdoc Travel Award
- 2004, University of Maryland, Baltimore, Graduate Merit Award for 2003-2004 academic year
- 2001, Degree Award: awarded for completing the undergraduate program in the first degree, Ege University
- 1997, University Entrance Examination Award: awarded for obtaining the highest score in the University Entrance Examination
Yöneterek Sonuçlandırdığı Öğrenci Tezleri (3 adet)- Doktora, 2014, İkinci Danışmanlık, Fadime Aydın Köse, Investigation of the Relationship between oxidative/nitrosative and Endoplasmic Reticulum (ER) stress and the function of MANF/ARMET as an ER sress response protein in ischemic acute renal failure/ İskem...
- Yüksek Lisans, 2013, Yalçın Erzurumlu, “Expression and purification of Inclusion Body Myopathy With Paget’s Disease of the Bone and Frontotemporal Dementia (IBMPFD) associated some VCP mutant proteins by recombinant DNA technology and investigation of the in vitro ...
- Yüksek Lisans, 2010, Ahmet Uygar Örs “Investigation the effect of mutations causing Inclusion Body Myopathy with Paget’s Disease of Bone And Frontotemporal Dementia (IBMPFD) on Endoplasmic Reticulum Associated Degradation (ERAD)/ Kemik paget hastalığı ve frontot...